 |
Prodcuts |
 |
Natural product scaffolds and advanced intermediates
Natural products or compounds that can be designed and developed from a model inspired by natural products, are of great importance in the development of new therapeutics for screening against various molecular targets. During the last two decades a number of block buster drugs that have been successfully developed and introduced to the market are either derived from natural products or a model inspired by natural products. CreaGen has expertise in designing synthetic routes to functionalized scaffolds and synthesizing focused libraries from these scaffolds. CreaGen is establishing collaborative relationships with academic groups and small companies in India to gain access to natural product scaffolds. We currently have a set of compounds in this category.
more...
|
Indoles and their advanced intermediates
Indoles are an important class of biologically active compounds and are a frequently found motif in natural products. Substituted indoles are of considerable interest as NK-1 antagonists for the treatment of pain, asthma, arthritis and migraine. They are also useful intermediates for the synthesis of nonsteroidal anti-inflammatory drugs (NSAIDs) such as Etodolac and Pemedolac. We have developed efficient procedures for the synthesis of 3,5-disubstituted indole-2-carboxylates and substituted 2-acetylindoles. CreaGen has extensive experience in desigining novel indole scaffolds with multiple points of diversity. We also have a set of optimized compound libraries available for immediate screening purposes.
more...
|
Pharmaceutical Intermediates (APIs) with multiple reactive sites
Samples of bulk drugs and advanced intermediates can serve as great scaffolds for parallel chemistry. They are not readily available to medicinal chemists as there are no commercial sources. They have the structural framework and pharmacophore necessary to satisfy Lipinski's rules for making the molecules more drug-like, have recognized pharmacology and toxicity profiles, established safety and efficacy, and proven feasibility for large-scale syntheses. CreaGen has established a relationship with pharmaceutical companies and academic institutes in India and China to acquire these intermediates and further modify them to create a set of optimized compounds for screening against various molecular targets. Compounds with potential for antibiotic activity are are available for immediate screening.
more...
|
Bifunctional pyridine boronic acids and advanced intermediates from pyridine boronic acids
Suzuki reactions are powerful methods for C-C bond formation. There has been a wealth of recent examples that further extend the utility and scope of the Suzuki reaction, to encompass the preparation of heterocyclic compounds and the introduction of alkoxycarbonyl-protected beta-aminoethyl groups into arenes and alkenes.
We have recently expanded our selection of aryl boronic acids to include a wide variety of unique bifunctional pyridine boronic acids. Incorporation of a carboxylic acid, a free hydroxyl group or a amino group into the pyridine boronic acid scaffold permits efficient two-point functionalization of the heterocyclics, which allows facile access to libraries.
CreaGen has developed a proprietary process for the efficient synthesis of these analogs along with other unique heterocyclic boronic acids. Inquiries are always welcome if the product of your choice is not listed or if you require large quantites.
more...
|
Triazoles and tetrazoles
These heterocycles are often found in kinase inhibitors. They are core structures also found in agro chemicals. CreaGen has developed a small set of optimized libraries containing these nuclei for target specific screening.
more...
|
Synthetic Scaffolds
more...
|
|
|
|
|
Company Profile |
|
 |
CreaGen Biosciences, Inc. is located in Woburn, MA, on the near north side of the Greater Boston Area. Boston is one of the primary hubs in the world for life sciences research.
(Corporate Fact Sheet)
more...
|
|
|
News |
|
 MassBi CRO CMO Symposium: February 25th, 2013
CreaGen Biosciences’ CEO is Co-Chair of the Second Annual Massachusetts CRO/CMO Symposium
CreaGen Biosciences will be one of the 40+ companies exhibiting at the February 25th event that showcases the local service providers from the greater MA life sciences cluster
http://www.massbio.org/events/calendar/1764-ma_cro_cmo_symposium/event_detail/452. more... |
|
2012
Raj Rajur attends TiECON East Conference as Charter Member together with Governor Deval Patrick.
Several Pictures from the Event: more... |
|
2012
MA CRO/CMO Symposium: Accelerating Drug Development
A One Day Symposium Presented by MassBio's Massachusetts CRO CMO Committee
Symposium will feature addresses by:
Deval Patrick, Governor of Massachusetts or Timothy Murray, Lieutenant Governor State of Massachusetts
The Conference Center at Bentley University, 75 Forest Street, LaCava 300, Waltham, MA 02452
March 6, 2012 7:30 a.m. to 4:00 p.m.
More Details more... |
|
| |
| |
|
